We designed and synthesized a series of novel 3-arylquinoxaline derivatives and evaluated\ntheir biological activities as potential dengue virus (DENV) replication inhibitors. Among them,\n[3-(4-methoxyphenyl)quinoxalin-2-yl](phenyl)methanol (19a), [6,7-dichloro-3-(4-methoxyphenyl)quinoxalin-\n2-yl](phenyl)methanol (20a), and (4-methoxyphenyl)(3-phenylquinoxalin-2-yl)methanone (21b) were found\nto significantly inhibit the DENV RNA expression in Huh-7-DV-Fluc cells with a potency better than that of\nribavirin. Compound 19a reduced DENV replication in both viral protein and messenger RNA (mRNA)\nlevels in a dose-dependent manner and exhibited no significant cell cytotoxicity. Notably, compound 19a\nexhibited a half maximal effective concentration (EC50) value������
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